Aromatase Inhibitors LiverTox NCBI Bookshelf

For women with breast cancer, there is growing evidence aromatase inhibitors are more effective than tamoxifen, the drug traditionally used to prevent breast cancer recurrence. In addition, clinical research is pointing to a day where aromatase inhibitors may be used to prevent breast cancer in postmenopausal women who are at an increased risk of the disease. Aromatase inhibitors are a class of drug used to prevent cancer recurrence in postmenopausal women with estrogen receptor-positive breast cancer. These medications also are prescribed for premenopausal women in combination with ovarian suppression therapy and for men with breast cancer who are unable to take tamoxifen.

  • How you have treatment depends on the type of hormone therapy you have.
  • This is done by comparing your details with those of more than 20,000 other people who have had treatment for breast cancer.
  • Anastrozole may affect your blood pressure, cholesterol and bone density.
  • In women who have not undergone menopause, estrogen is produced mainly in the ovaries and, to a lesser degree, in peripheral tissues such as the breasts, liver, brain, skin, bone, and pancreas.
  • Talk with your health care provider about how long you should take an aromatase inhibitor.
  • Learn about aromatase inhibitors and other hormone therapies for metastatic breast cancer.

When used to lower breast cancer risk, these drugs are typically taken for 5 years. If you are bothered by side effects from taking anastrozole, talk to your doctor. In this case, surgery, radiotherapy or chemotherapy is the first (primary) treatment and anastrozole is an additional (adjuvant) therapy.

This side effect can be serious enough to cause some women to stop taking the drugs. The three aromatase inhibitors are discussed separately, and references to their hepatotoxicity and safety are given in each section. A few general references are provided at the end of this Overview section. Anastrozole is sometimes used to treat cancer if you cannot have surgery, or to shrink the cancer before surgery if you cannot have chemotherapy.

Joint and muscle pain

Clinical trials have shown that aromatase inhibitors are about 30% more effective in preventing breast cancer recurrence than tamoxifen or raloxifene. For that reason, aromatase inhibitors are the preferred treatment for post-menopausal women with estrogen-fueled breast cancers. Aromatase inhibitors are approved to reduce the risk of recurrence in postmenopausal women with estrogen receptor-positive breast cancer. They can also be used to treat advanced breast cancer, including stage 4 breast cancer, in which the malignancy has spread (metastasized) to other parts of the body.

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].

Buy Letrozol 2.5 mg USA bind to aromatase and stop the process of conversion to estrogen. This keeps estrogen levels down and helps prevent cancer cells from getting the estrogen they can use to grow and spread. Most estrogen comes from the ovaries, but it’s not the only source.

What are Aromatase inhibitors?

If your cancer has spread to other parts of your body, hormone therapy for breast cancer may help control it. Although aromatase inhibitors can cause joint and muscle pain, they don’t cause permanent joint or muscle damage. We talked with Layman to learn more about these hormone therapy drugs, which are available only to women who’ve completed menopause. Men with breast cancer may be given an aromatase inhibitor, although another drug called tamoxifen is more commonly used.